反应详情

2,3-Dichloro-5-trifluoromethylpyridine (1.04 g), 0.8 g of 2,6-dimethyl-4-nitrophenol, and 0.5 g of potassium carbonate were added to 3 mL of dimethylacetamide, and the mixture was allowed to react at 155 to 165° C. for one hr. The reaction mixture was cooled, ethyl acetate and distilled water were then added thereto, followed by separation and washing with brine. The ethyl acetate layer was concentrated to give 2.01 g of 3-chloro-2-(2,6-dimethyl-4-nitrophenoxy)-5-trifluoromethylpyridine (yield 100%).

1. customto react at 155 to 165° C. for one hr
2. temperatureThe reaction mixture was cooled
3. distillationethyl acetate and distilled water
4. additionwere then added
5. customfollowed by separation
6. washwashing with brine
7. concentrationThe ethyl acetate layer was concentrated