Ammonia → 3-(1-Adamantyl)-5-(2-pyridyl)-1-phenyl-1,2-dihydropyridin-2-one

HRID 136253Notes

Reaction equation

HRID 136253 reaction equation
[Br-:21].[Br:1][c:2]1[c:3](=[O:20])[n:4](-[c:14]2[cH:15][cH:16][cH:17][cH:18][cH:19]2)[cH:5][c:6](-[c:8]2[n:9][cH:10][cH:11][cH:12][cH:13]2)[cH:7]1.[C:22]12([Zn+:32])[CH2:23][CH:24]3[CH2:25][CH:26]([CH2:27][CH:28]([CH2:29]1)[CH2:30]3)[CH2:31]2.[Cu:39][I:40].[NH3:33].[O:34]1[CH2:35][CH2:36][CH2:37][CH2:38]1>>[c:2]1([C:22]23[CH2:23][CH:24]4[CH2:25][CH:26]([CH2:27][CH:28]([CH2:29]2)[CH2:30]4)[CH2:31]3)[c:3](=[O:20])[n:4](-[c:14]2[cH:15][cH:16][cH:17][cH:18][cH:19]2)[cH:5][c:6](-[c:8]2[n:9][cH:10][cH:11][cH:12][cH:13]2)[cH:7]1

Participants

7

Reactant 6

HCID 222AmmoniaHCID 259Bromide ionHCID 8028TetrahydrofuranHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 223190653-Bromo-1-phenyl-5-(pyridin-2-yl)-1,2-dihydropyridin-2-oneHCID 178528050HCID 178528050, compound

Product 1

HCID 223192453-(1-Adamantyl)-5-(2-pyridyl)-1-phenyl-1,2-dihydropyridin-2-one

Sources & evidence

ORD record
ord-a93afd06c92a49edaa851e80fce574ce
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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