Dichloromethane → HCID 57572396, compound

HRID 1363076Notes

Reaction equation

HRID 1363076 reaction equation
[Cl:1][C:2]1[S:6][C:5]([C:7]([NH:9][C:10]2[C:18]3[C:13](=[CH:14][CH:15]=[C:16]([C:19]4[O:23][C:22]([C:24]([O:26]C(C)(C)C)=[O:25])=[CH:21][CH:20]=4)[CH:17]=3)[NH:12][N:11]=2)=[O:8])=[CH:4][CH:3]=1.ClCCl>FC(F)(F)C(O)=O>[Cl:1][C:2]1[S:6][C:5]([C:7]([NH:9][C:10]2[C:18]3[C:13](=[CH:14][CH:15]=[C:16]([C:19]4[O:23][C:22]([C:24]([OH:26])=[O:25])=[CH:21][CH:20]=4)[CH:17]=3)[NH:12][N:11]=2)=[O:8])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 6344DichloromethaneHCID 57572393HCID 57572393, compound

Product 1

HCID 57572396HCID 57572396, compoundYield 99.7%

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

240 mg of tert-butyl 5-{3-[(5-chlorothiophene-2-carbonyl)amino]-1H-indazol-5-yl}furan-2-carboxylate are dissolved in 1 ml of trifluoroacetic acid and 3 ml of dichloromethane and stirred at room temperature for 24 hours. The batch is evaporated, the residue is stirred with dichloromethane, filtered off with suction and dried, giving 209 mg of 5-{3-[(5-chlorothiophene-2-carbonyl)amino]-1H-indazol-5-yl}furan-2-car-boxylic acid (“A20”) (quant.).

Workup

  1. customThe batch is evaporated
  2. filtrationfiltered off with suction
  3. customdried

Sources & evidence

ORD record
ord-ca4694bc6a804fbc842250810fe6eb3d
Source dataset
uspto-grants-2011_02
Patent number
US07884126B2

Reaction notes

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