Trifluoroacetic acid → HCID 66970457, compound

HRID 1363182Notes

Reaction equation

HRID 1363182 reaction equation
COC1C=C(OC)C=CC=1C[NH:6][C:7]1[CH:12]=[C:11]([F:13])[CH:10]=[CH:9][C:8]=1[NH:14][C:15]1[N:23]=[C:22]2[C:18]([NH:19][C:20](=[O:35])[N:21]2[C@H:24]2[C:33]3[C:28](=[C:29]([F:34])[CH:30]=[CH:31][CH:32]=3)[O:27][CH2:26][CH2:25]2)=[CH:17][N:16]=1.C(O)(C(F)(F)F)=O.C([SiH](CC)CC)C>>[NH2:6][C:7]1[CH:12]=[C:11]([F:13])[CH:10]=[CH:9][C:8]=1[NH:14][C:15]1[N:23]=[C:22]2[C:18]([NH:19][C:20](=[O:35])[N:21]2[C@H:24]2[C:33]3[C:28](=[C:29]([F:34])[CH:30]=[CH:31][CH:32]=3)[O:27][CH2:26][CH2:25]2)=[CH:17][N:16]=1

Participants

4

Reactant 3

HCID 6422Trifluoroacetic acidHCID 12052TriethylsilaneHCID 66970763HCID 66970763, compound

Product 1

HCID 66970457HCID 66970457, compound

Procedure

A mixture of (R)-2-(2-(2,4-dimethoxybenzylamino)-4-fluorophenylamino)-9-(8-fluorochroman-4-yl)-7H-purin-8(9H)-one (14 mg) and TFA (1 mL) was stirred for 60 min when triethyl silane (0.5 mL) was added. The resulting solution was stirred at RT for 16 hr, then the solvents were reduced in vacuo to yield (R)-2-(2-amino-4-fluorophenylamino)-9-(8-fluorochroman-4-yl)-7H-purin-8(9H)-one that was used as such.

Workup

  1. additionwas added

Sources & evidence

ORD record
ord-1001add6400f4fe4acda839ff3a9644c
Source dataset
uspto-grants-2011_02
Patent number
US07884109B2

Reaction notes

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