反应详情

To a solution of the 2-(6-fluoro-1H-benzo[d]imidazol-1-yl)-N—((R)-8-fluorochroman-4-yl)-5-nitropyrimidin-4-amine in EtOAc (20 mL) was added 5 mol % of Platinum, 5% on activated carbon power, sulfide, 0.5% S (as sulfide) (45.6 mg). The mixture was sparged with argon, transferred to the Parr hydrogenation apparatus, then subjected to a purge/fill sequence with hydrogen (repeated 5×). The mixture was hydrogenated for 18 hr at 40 psi. Filtration through a pad of Celite and concentration of the filtrate gave crude 2-(6-fluoro-1H-benzo[d]imidazol-1-yl)N4—((R)-8-fluorochroman-4-yl)pyrimidine-4,5-diamine that was carried on without further purification. MH+=425.

1. customThe mixture was sparged with argon
2. filtrationFiltration through a pad of Celite and concentration of the filtrate