Hydrazine hydrate (1:1) → HCID 66970518, compound

HRID 1363198Notes

Reaction equation

HRID 1363198 reaction equation
C([N:4]([C@@H:12]1[CH2:21][CH2:20][CH2:19][C:18]2[N:17]=[CH:16][CH:15]=[N:14][C:13]1=2)[C:5](=[O:11])[O:6][C:7]([CH3:10])([CH3:9])[CH3:8])(=O)C.O.NN>CO.CCOC(C)=O>[N:17]1[C:18]2[CH2:19][CH2:20][CH2:21][C@@H:12]([NH:4][C:5](=[O:11])[O:6][C:7]([CH3:9])([CH3:8])[CH3:10])[C:13]=2[N:14]=[CH:15][CH:16]=1

Participants

5

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 66970497HCID 66970497, compound

Product 1

HCID 66970518HCID 66970518, compoundYield 94.9%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

A solution of (R)-tert-butyl acetyl(5,6,7,8-tetrahydroquinoxalin-5-yl)carbamate (293 mg) in methanol (10 mL) was treated with hydrazine hydrate (0.5 mL) for 1.5 h. The mixture was diluted with EtOAc and washed twice with saturated aqueous sodium chloride. The organic layer was separated, dried with sodium sulfate, and concentrated in vacuo to provide 238 mg of the title compound.

Workup

  1. washwashed twice with saturated aqueous sodium chloride
  2. customThe organic layer was separated
  3. dry with materialdried with sodium sulfate
  4. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-7a02c54118bf4682b46750f89475d487
Source dataset
uspto-grants-2011_02
Patent number
US07884109B2

Reaction notes

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