Trifluoroacetic acid → HCID 66970592, compound

HRID 1363221Notes

Reaction equation

HRID 1363221 reaction equation
O1CCOC1.[F:6][C:7]1[CH:12]=[CH:11][C:10]([NH:13]C(=O)OC(C)(C)C)=[C:9]([NH:21][C:22]2[N:27]=[C:26]([NH:28][C@H:29]3[C:38]4[C:33](=[CH:34][CH:35]=[CH:36][CH:37]=4)[C:32](=[O:39])[CH2:31][CH2:30]3)[C:25]([N+:40]([O-:42])=[O:41])=[CH:24][N:23]=2)[CH:8]=1.C(O)(C(F)(F)F)=O>C(Cl)Cl>[NH2:13][C:10]1[CH:11]=[CH:12][C:7]([F:6])=[CH:8][C:9]=1[NH:21][C:22]1[N:27]=[C:26]([NH:28][C@H:29]2[C:38]3[C:33](=[CH:34][CH:35]=[CH:36][CH:37]=3)[C:32](=[O:39])[CH2:31][CH2:30]2)[C:25]([N+:40]([O-:42])=[O:41])=[CH:24][N:23]=1

Participants

5

Reactant 3

HCID 6422Trifluoroacetic acidHCID 125861,3-DioxolaneHCID 66970493HCID 66970493, compound

Product 1

HCID 66970592HCID 66970592, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of 1,3-dioxolane of (R)-tert-butyl 4-fluoro-2-(5-nitro-4-(4-oxo-1,2,3,4-tetrahydronaphthalen-1-ylamino)pyrimidin-2-ylamino)phenylcarbamate (145 mg) and TFA (2.5 mL) in CH2Cl2 (5 mL) was stirred at room temperature for 1 h. Volatiles were removed in vacuo and the crude (120 mg) was subjected to the next step without further purification.

Workup

  1. customVolatiles were removed in vacuo
  2. customthe crude (120 mg) was subjected to the next step without further purification

Sources & evidence

ORD record
ord-a67c01c445404b18a1ddfff1c378f89a
Source dataset
uspto-grants-2011_02
Patent number
US07884109B2

Reaction notes

Loading…