反应详情

Compound of example 152 (6.5 g, 28.1 mmol) was dissolved in dry 1,4-dioxane (50 mL) under dry N2 atmosphere. To this solution, NaH (50%, 3.37 g, 70.20 mmol) was added in portions at 25° C. and the mixture was stirred for 10 min. Dimethyl sulfate (4 mL, 5.31 g, 40.48 mmol) was added and the reaction mixture was stirred at 50° C. for 1 h. It was poured into ice water, acidified using 6N HCl and extracted using EtOAc (3×100 mL). The organic extract was washed with water, dried (anhydrous Na2SO4), concentrated and purified using a silica gel column and 5% EtOAc in petroleum ether (60-80° C.) as eluant to obtain the title compound.

1. stirringthe reaction mixture was stirred at 50° C. for 1 h
2. extractionextracted
3. extractionThe organic extract
4. washwas washed with water
5. dry with materialdried (anhydrous Na2SO4)
6. concentrationconcentrated
7. custompurified
8. customa silica gel column and 5% EtOAc in petroleum ether (60-80° C.)