Hydrochloric Acid → HCID 15979659, compound

HRID 1363470Notes

Reaction equation

HRID 1363470 reaction equation
[ClH:1].C([O:6][C:7]([C:9]1[C:10]([C:15]2[CH:20]=[CH:19][C:18]([CH2:21][N:22]3[C:26]4[CH:27]=[C:28]([C:32]5[N:36]([CH3:37])[C:35]6[CH:38]=[CH:39][CH:40]=[CH:41][C:34]=6[N:33]=5)[CH:29]=[C:30]([CH3:31])[C:25]=4[N:24]=[C:23]3[CH2:42][CH2:43][CH3:44])=[CH:17][CH:16]=2)=[CH:11][CH:12]=[CH:13][CH:14]=1)=[O:8])(C)(C)C.Cl>CC(C)=O>[ClH:1].[ClH:1].[CH3:31][C:30]1[C:25]2[N:24]=[C:23]([CH2:42][CH2:43][CH3:44])[N:22]([CH2:21][C:18]3[CH:17]=[CH:16][C:15]([C:10]4[C:9]([C:7]([OH:8])=[O:6])=[CH:14][CH:13]=[CH:12][CH:11]=4)=[CH:20][CH:19]=3)[C:26]=2[CH:27]=[C:28]([C:32]2[N:36]([CH3:37])[C:35]3[CH:38]=[CH:39][CH:40]=[CH:41][C:34]=3[N:33]=2)[CH:29]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86626443HCID 86626443, compound

Product 1

HCID 15979659HCID 15979659, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Conditions

Temperature
27.5 °C

Procedure

Tert.Butyl-4′-[4-Methyl-6-(1-methyl-1H-benzimidazol-2-yl)-2-n-propyl-1H-benzimidazol-1-yl-methyl]biphenyl-2-carboxylate hydrochloride (50 gms) is suspended in acetone (250 ml) and hydrochloric acid (50 ml) is added. Temperature of the mass is raised, maintained at 50° C.-55° C. for 3 hrs, cooled and maintained at 25-30° C. for 2 hrs. Product is filtered; wet cake is washed with water (2×50 ml) and acetone (50 ml). Dried the wet cake at temperature 60° C.-65° C. till constant weight.

Workup

  1. temperatureTemperature of the mass is raised
  2. temperaturemaintained at 50° C.-55° C. for 3 hrs
  3. temperaturecooled
  4. filtrationProduct is filtered
  5. washwet cake is washed with water (2×50 ml) and acetone (50 ml)
  6. customDried the wet cake at temperature 60° C.-65° C. till constant weight

Sources & evidence

ORD record
ord-91521102c9f2443eafa57cd80494c3da
Source dataset
uspto-grants-2011_02
Patent number
US07884214B2

Reaction notes

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