4-Nitro-4'-(trifluoromethoxy)-1,1'-biphenyl → 4'-Trifluoromethoxy-biphenyl-4-ylamine

HRID 1363650Notes

Reaction equation

HRID 1363650 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[CH:15]=[CH:14][C:13]([O:16][C:17]([F:20])([F:19])[F:18])=[CH:12][CH:11]=2)=[CH:6][CH:5]=1)([O-])=O>[Pt].CO>[NH2:1][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[CH:15]=[CH:14][C:13]([O:16][C:17]([F:18])([F:19])[F:20])=[CH:12][CH:11]=2)=[CH:6][CH:5]=1

Participants

4

Reactant 1

HCID 598208424-Nitro-4'-(trifluoromethoxy)-1,1'-biphenyl

Product 1

HCID 27607274'-Trifluoromethoxy-biphenyl-4-ylamineYield 96%

Reagents, catalysts & solvents 2

HCID 23939PlatinumCatalystHCID 887MethanolSolvent

Procedure

A mixture of 4-nitro-4′-(trifluoromethoxy)biphenyl (6.41 g, 22.6 mmol), 10% platinum-activated charcoal (150 mg) and methanol (50 ml) was stirred for 16 hours under hydrogen atmosphere. The reaction mixture was filtered through celite. The filtrate was concentrated under reduced pressure to give the title compound (5.48 g, 96%) as a white solid.

Workup

  1. filtrationThe reaction mixture was filtered through celite
  2. concentrationThe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-57ed8431cf964a1ba2aa640295566c92
Source dataset
uspto-grants-2011_02
Patent number
US07884234B2

Reaction notes

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