Sodium cyanoborohydride → HCID 62390706, compound

HRID 1363676Notes

Reaction equation

HRID 1363676 reaction equation
[CH2:1]([C:3]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:4]=1[CH2:5][CH2:6][C:7]2=O)[CH3:2].[BH3-]C#[N:15].[Na+]>C(O)(C)C>[CH2:1]([C:3]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:4]=1[CH2:5][CH2:6][CH:7]2[NH2:15])[CH3:2]

Participants

4

Reactant 2

HCID 5003444Sodium cyanoborohydrideHCID 19802539HCID 19802539, compound

Product 1

HCID 62390706HCID 62390706, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

4-Ethyl-indan-1-one (5.00 g, 31.21 mmol), NaBH3CN (13.70 g, 0.22 mol) and NH4OAc (72.00 g, 0.93 mol) in isopropanol were reacted according to the protocols as outlined in general procedure B to give the desired amine.

Sources & evidence

ORD record
ord-e283091860054e5983323e39d0f1e645
Source dataset
uspto-grants-2011_02
Patent number
US07884244B2

Reaction notes

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