HRID1363755

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID7604

3-Aminoacetanilide

C8H10N2O

HCID70106

Cyclopentanecarbaldehyde

C6H10O

HCID57481428

Ethyl 3-[(2-amino-1,3-thiazol-5-yl)sulfanyl]propanoate

C8H12N2O2S2

结构：O=C(O)Cc1csc(NC(=O)N(CC2CCCC2)c2ccc(F)c(F)c2)n1

HCID57668246

未命名化合物

结构：CCOC(=O)CCSc1cnc(NC(=O)N(CC2CCCC2)c2cccc(NC(C)=O)c2)s1

HCID86629888

未命名化合物

PRODUCTS

生成物

结构：CC(=O)Nc1cccc(N(CC2CCCC2)C(=O)Nc2ncc(SCCC(=O)O)s2)c1

HCID57668415

未命名化合物

PROCEDURE

实验过程

The title compound was prepared via 3-{2-[3-(3-acetylamino-phenyl)-3-cyclopentylmethyl-ureido]-thiazol-5-ylsulfanyl}-propionic acid ethyl ester in a similar manner as described for the synthesis of {2-[3-cyclopentylmethyl-3-(3,4-difluoro-phenyl)-ureido]-thiazol-4-yl}-acetic acid, using N-(3-amino-phenyl)-acetamide, cyclopentanecarbaldehyde and 3-(2-amino-thiazol-5-ylsulfanyl)-propionic acid ethyl ester.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-919d525567a44db28b19af69a5043862
来源数据集: uspto-grants-2011_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07884210B2
来源说明: uspto-grants-2011_02

反应 SMILES

C([O:3][C:4](=[O:33])[CH2:5][CH2:6][S:7][C:8]1[S:12][C:11]([NH:13][C:14]([N:16]([C:23]2[CH:28]=[CH:27][CH:26]=[C:25]([NH:29][C:30](=[O:32])[CH3:31])[CH:24]=2)[CH2:17][CH:18]2[CH2:22][CH2:21][CH2:20][CH2:19]2)=[O:15])=[N:10][CH:9]=1)C.C1(CN(C2C=CC(F)=C(F)C=2)C(=O)NC2SC=C(CC(O)=O)N=2)CCCC1.NC1C=C(NC(=O)C)C=CC=1.C1(C=O)CCCC1.C(OC(=O)CCSC1SC(N)=NC=1)C>>[C:30]([NH:29][C:25]1[CH:24]=[C:23]([N:16]([CH2:17][CH:18]2[CH2:22][CH2:21][CH2:20][CH2:19]2)[C:14](=[O:15])[NH:13][C:11]2[S:12][C:8]([S:7][CH2:6][CH2:5][C:4]([OH:33])=[O:3])=[CH:9][N:10]=2)[CH:28]=[CH:27][CH:26]=1)(=[O:32])[CH3:31]