Triethylamine → HCID 66958192, compound

HRID 1364039Notes

Reaction equation

HRID 1364039 reaction equation
[CH3:1][S:2](Cl)(=[O:4])=[O:3].Cl.[CH:7]1[CH:16]=[CH:15][CH:14]=[C:13]2[C:8]=1[C:9]1[N:19]3[CH2:20][CH2:21][CH2:22][NH:23][CH2:24][C:18]3=[N:17][C:10]=1[CH:11]=[N:12]2.C(N(CC)CC)C>CN(C=O)C>[CH3:1][S:2]([N:23]1[CH2:22][CH2:21][CH2:20][N:19]2[C:9]3[C:8]4[C:13](=[CH:14][CH:15]=[CH:16][CH:7]=4)[N:12]=[CH:11][C:10]=3[N:17]=[C:18]2[CH2:24]1)(=[O:4])=[O:3]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 66958459HCID 66958459, compound

Product 1

HCID 66958192HCID 66958192, compoundYield 35.6%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Methanesulfonyl chloride (2.54 mL, 32.6 g) was added to a solution of 9,10,11,12-tetrahydro-8H-[1,4]diazepino[1′,2′:1,2]imidazo[4,5-c]quinoline hydrochloride (7.47 g, 27.2 mmol) and triethylamine (22.73 mL, 163.1 mmol) in DMF (50 mL). The reaction was stirred overnight at ambient temperature and then concentrated under reduced pressure to provide 3.065 g of 9-(methylsulfonyl)-9,10,11,12-tetrahydro-8H-[1,4]diazepino[1′,2′:1,2]imidazo[4,5-c]quinoline.

Workup

  1. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-39e8337942144878b087f7e1c68c342c
Source dataset
uspto-grants-2011_02
Patent number
US07888349B2

Reaction notes

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