Water → HCID 11572729, compound

HRID 1364399Notes

Reaction equation

HRID 1364399 reaction equation
[C:1](#[N:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:9](=[O:12])(O)O.[NH2:13][C:14]([NH2:16])=[NH:15].O.C(O[CH2:22][CH3:23])(=O)C>CC(N(C)C)=O>[N:8]1[CH:1]=[CH:2][CH:7]=[CH:6][C:5]=1[CH:4]([O:12][C:9]1[CH:23]=[CH:22][CH:4]=[C:3]2[C:2]=1[C:1]([NH2:8])=[N:15][C:14]([NH2:16])=[N:13]2)[CH3:3]

Participants

6

Reactant 4

HCID 962WaterHCID 7505BenzonitrileHCID 8857Ethyl AcetateHCID 286947Carbonic acid-guanidine (1:1)

Product 1

HCID 11572729HCID 11572729, compound

Reagents, catalysts & solvents 1

HCID 31374DimethylacetamideSolvent

Procedure

The previous benzonitrile (30.2 mg; 0.12 mmol) and guanidine carbonate (45 mg; 2.5 mmol) were heated at 120° C. in dimethyl acetamide for 4 hours. The reaction mixture was cooled to room temperature and water and ethyl acetate added. Extracted with ethyl acetate and solvent removed to yield 25 milligrams of 5-(1-pyridin-2-ylethoxy)quinazoline-2,4-diamine.

Workup

  1. extractionExtracted with ethyl acetate and solvent
  2. customremoved

Sources & evidence

ORD record
ord-5d864d344ac6414c890f16409decba1e
Source dataset
uspto-grants-2011_02
Patent number
US07888366B2

Reaction notes

Loading…