反应详情

温度

150 °C

A heavy walled, sealable tube suitable for microwave heating was charged with 6 mL of 2-propanol and 150 mg (6.5 mmol) of sodium. The mixture was stirred at 95° C. until all of the sodium had reacted (15 minutes), then 650 mg (3.05 mmol) of 2-bromo-4,6-diaminonicotinonitrile was added. The tube was sealed, and the mixture was heated with a microwave apparatus at 150° C. for 10 minutes then cooled and diluted with 30 mL of water. The precipitate was collected, washed with water until pH=7, then dried under reduced pressure at 95° C. to provide 312 mg (53%) of pale yellow crystals.

1. temperatureA heavy walled, sealable tube suitable for microwave heating
2. customhad reacted (15 minutes)
3. customThe tube was sealed
4. temperaturethen cooled
5. customThe precipitate was collected
6. washwashed with water until pH=7
7. customdried under reduced pressure at 95° C.