Bicarbonate Ion → 2-fluoro-3-[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]-N-[2-oxo-3-(2,4,6-trifluorophenyl)piperidin-1-yl]prop-2-enamide
Reaction equation
[C:39](=[O:40])([OH:41])[O-:42].[CH3:44][CH2:45][O:46][C:47](=[O:48])[CH3:49].[F:1][C:2]([C:3](=[O:4])[OH:5])=[CH:6][c:7]1[cH:8][c:9]([O:19][CH3:20])[c:10](-[n:13]2[cH:14][n:15][c:16]([CH3:18])[cH:17]2)[cH:11][cH:12]1.[NH2:21][N:22]1[C:23](=[O:37])[CH:24]([c:28]2[c:29]([F:36])[cH:30][c:31]([F:35])[cH:32][c:33]2[F:34])[CH2:25][CH2:26][CH2:27]1.[Na+:43].[O:50]=[CH:51][N:52]([CH3:53])[CH3:54].[OH2:38]>>[F:1][C:2]([C:3](=[O:5])[NH:21][N:22]1[C:23](=[O:37])[CH:24]([c:28]2[c:29]([F:36])[cH:30][c:31]([F:35])[cH:32][c:33]2[F:34])[CH2:25][CH2:26][CH2:27]1)=[CH:6][c:7]1[cH:8][c:9]([O:19][CH3:20])[c:10](-[n:13]2[cH:14][n:15][c:16]([CH3:18])[cH:17]2)[cH:11][cH:12]1Participants
8
Reactant 7
Product 1
Sources & evidence
- ORD record
- ord-09561020890e44749139fd5627aefc2e
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (9/10)
Reaction notes
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