反应详情

温度

0 °C

Methyl triphenylphosphonium bromide (6.3 g, 17.6 mmol) was dissolved in 150 mL THF and cooled to 0° C. KHMDS (3.2 g, 16.2 mmol) was added portionwise and the reaction was stirred for ½ hour. The product of Example 1, step (c) (3.0 g, 12.5 mmol) was added as a solution in 25 μL THF. The reaction was warmed to room temperature and stirred for 1 hour. The mixture was concentrated and the title product was purified by silica gel chromatography (0% to 40% EtOAc in hexanes) to give 2.6 g of the sub-title compound.

1. temperatureThe reaction was warmed to room temperature
2. stirringstirred for 1 hour
3. concentrationThe mixture was concentrated
4. customthe title product was purified by silica gel chromatography (0% to 40% EtOAc in hexanes)