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HRID1365924

反应详情

EQUATION

反应方程式

HRID 1365924 的结构方程式

REACTANTS

反应物

4
结构：O=C([O-])O.[Na+]
HCID516892

Sodium Bicarbonate

CHNaO3

结构：O=S(=O)(O)O[O-].O=S(=O)(O)O[O-].O=S(=O)([O-])O.O=S(=O)([O-])[O-].[K+].[K+].[K+].[K+].[K+]
HCID15793144

Potassium hydrogen monopersulfate

H3K5O18S4

结构：O=S([O-])O.[Na+]
HCID23665763

Sodium Bisulfite

HNaO3S

结构：CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H]1CN(C(=O)N2CCSCC2)C[C@H]1c1ccc(F)cc1
HCID59840137

未命名化合物

PRODUCTS

生成物

1
结构：CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H]1CN(C(=O)N2CCS(=O)(=O)CC2)C[C@H]1c1ccc(F)cc1
HCID59840073

未命名化合物

收率 88%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CO
溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

To a stirred solution of rac-2-(3,5-bis-trifluoromethyl-phenyl)-N-[(3S,4R)-4-(4-fluoro-phenyl)-1-(thiomorpholine-4-carbonyl)-pyrrolidin-3-yl]-N-methyl-isobutyramide (0.20 g, 0.33 mmol, described herein above) in MeOH (2 ml) at RT, was added potassium monopersulfate triple salt (0.30 g, 0.49 mmol). Stirring was continued an additional 3 hours, then a solution of NaHSO3 (40%) was added, the ph was adjusted to 9 with an aqueous solution of NaHCO3, and finally the product was extracted with Et2O. Purification by flash chromatography (SiO2, EtOAc/Hx 1:1) yielded 185 mg (88%) of the title compound as_white foam.

WORKUP

后处理

  1. extractionfinally the product was extracted with Et2O
  2. customPurification by flash chromatography (SiO2, EtOAc/Hx 1:1)