HCID 59411295, compound → HCID 59411327, compound

HRID 1366258Notes

Reaction equation

HRID 1366258 reaction equation
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([CH:9]2[N:14]([CH2:15][C:16]3[CH:17]=[C:18]([CH:26]=[CH:27][CH:28]=3)[C:19]([O:21]C(C)(C)C)=[O:20])[C:13](=[O:29])[N:12]([C:30]3[CH:35]=[CH:34][CH:33]=[C:32]([C:36]([F:39])([F:38])[F:37])[CH:31]=3)[C:11]([CH3:40])=[C:10]2[C:41]([C:43]2[O:44][CH:45]=[CH:46][CH:47]=2)=[O:42])=[CH:5][CH:4]=1)#[N:2]>FC(F)(F)C(O)=O>[C:1]([C:3]1[CH:8]=[CH:7][C:6]([CH:9]2[N:14]([CH2:15][C:16]3[CH:17]=[C:18]([CH:26]=[CH:27][CH:28]=3)[C:19]([OH:21])=[O:20])[C:13](=[O:29])[N:12]([C:30]3[CH:35]=[CH:34][CH:33]=[C:32]([C:36]([F:39])([F:38])[F:37])[CH:31]=3)[C:11]([CH3:40])=[C:10]2[C:41]([C:43]2[O:44][CH:45]=[CH:46][CH:47]=2)=[O:42])=[CH:5][CH:4]=1)#[N:2]

Participants

3

Reactant 1

HCID 59411295HCID 59411295, compound

Product 1

HCID 59411327HCID 59411327, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

tert-Butyl 3-{[6-(4-cyanophenyl)-5-(2-furoyl)-4-methyl-2-oxo-3-[3-(trifluoromethyl)phenyl]-3,6-dihydropyrimidin-1(2H)-yl]methyl}benzoate (Example 43) (50 mg, 0.078 mmol) is dissolved in trifluoroacetic acid (2 ml). After 15 minutes stirring, the solution is concentrated in vacuo and the residue is purified by preparative HPLC (RP18 column; eluent: acetonitrile/water 10:90→90:10).

Workup

  1. concentrationthe solution is concentrated in vacuo
  2. customthe residue is purified by preparative HPLC (RP18 column; eluent: acetonitrile/water 10:90→90:10)

Sources & evidence

ORD record
ord-f032eba0972c40b7b0a5c4043ef7ef45
Source dataset
uspto-grants-2011_02
Patent number
US07893073B2

Reaction notes

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