Hydrochloric Acid → 1152111-52-8

HRID 1366551Notes

Reaction equation

HRID 1366551 reaction equation
C1(C(C2C=CC=CC=2)[N:8]2[CH2:11][C:10]([N:13]3[CH2:18][CH2:17][O:16][CH2:15][CH2:14]3)([CH3:12])[CH2:9]2)C=CC=CC=1.[ClH:25]>C(O)C.[OH-].[OH-].[Pd+2]>[ClH:25].[ClH:25].[CH3:12][C:10]1([N:13]2[CH2:18][CH2:17][O:16][CH2:15][CH2:14]2)[CH2:9][NH:8][CH2:11]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 66936171HCID 66936171, compound

Product 1

HCID 669364371152111-52-8Yield 74.9%

Reagents, catalysts & solvents 2

HCID 9942167Palladium hydroxideCatalystHCID 702EthanolSolvent

Procedure

A mixture of 4-[1-(diphenylmethyl)-3-methyl-3-azetidinyl]morpholine (1.05 g, 3.26 mmol), 10% Pd(OH)2 (0.12 g) in ethanol (30 ml) and 1N HCl (7 ml) was treated with H2 at 60 psi overnight. The catalyst was removed by filtration, and the solvent was evaporated under vacuum. The residue was washed with benzene (3×5 ml) and dried under high vacuum to provide 4-(3-methyl-3-azetidinyl)morpholine dihydrochloride (0.52 g, 74.9%). LCMS: (M+H)+ 156.9.

Workup

  1. additionwas treated with H2 at 60 psi overnight
  2. customThe catalyst was removed by filtration
  3. customthe solvent was evaporated under vacuum
  4. washThe residue was washed with benzene (3×5 ml)
  5. customdried under high vacuum

Sources & evidence

ORD record
ord-e3b9d7424cce4fec9084f26cfa47dcfa
Source dataset
uspto-grants-2011_02
Patent number
US07893056B2

Reaction notes

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