反应详情

A mixture of 1-[1-(diphenylmethyl)-3-methyl-3-azetidinyl]pyrrolidine (0.94 g, 3.07 mmol) and 20% Pd(OH)2 (0.11 g) in ethanol (30 ml) and 1N HCl (7 ml) was treated with H2 at 60 psi overnight. The catalyst was removed by filtration, and the filtrate was evaporated under vacuum. The residue was washed with benzene (3×5 ml) and dried under high vacuum to provide 1-(3-methyl-3-azetidinyl)pyrrolidine dihydrochloride (0.76 g, presumed 86% pure). LCMS: (M+H)+: 141.0.

1. additionwas treated with H2 at 60 psi overnight
2. customThe catalyst was removed by filtration
3. customthe filtrate was evaporated under vacuum
4. washThe residue was washed with benzene (3×5 ml)
5. customdried under high vacuum