Hydrochloric Acid → HCID 66935862, compound

HRID 1366621Notes

Reaction equation

HRID 1366621 reaction equation
[CH3:1][N:2]([CH3:18])[C:3]([CH:6]1[CH2:10][CH2:9][N:8](CC2C=CC=CC=2)[CH2:7]1)([CH3:5])[CH3:4].[ClH:19]>CO>[ClH:19].[CH3:18][N:2]([CH3:1])[C:3]([CH:6]1[CH2:10][CH2:9][NH:8][CH2:7]1)([CH3:5])[CH3:4]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 66936521HCID 66936521, compound

Product 1

HCID 66935862HCID 66935862, compoundYield 76.3%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

N,N-Dimethyl-2-[1-(phenylmethyl)-3-pyrrolidinyl]-2-propanamine (2.089 g, 8.47 mmol) was dissolved in a mixture of MeOH (50 mL) and 1N HCl (18.65 mL, 18.65 mmol), degassed and placed under argon. 10% Pd/C (625 mg) was added, and the contents were thoroughly degassed and placed under a hydrogen balloon for 2 h. The contents were then degassed, and the Pd/C was removed by filtration through a fiberglass filter, washing with MeOH. The filtrate was concentrated in vacuo to provide pure N,N-dimethyl-2-(3-pyrrolidinyl)-2-propanamine hydrochloride (1.245 g, 76%). LCMS: (M+H)+: 157.2.

Workup

  1. customdegassed
  2. addition10% Pd/C (625 mg) was added
  3. customthe contents were thoroughly degassed
  4. customfor 2 h
  5. customThe contents were then degassed
  6. customthe Pd/C was removed by filtration through a fiberglass
  7. filtrationfilter
  8. washwashing with MeOH
  9. concentrationThe filtrate was concentrated in vacuo

Sources & evidence

ORD record
ord-e3b6030e691245e68e8e55d1a13ce950
Source dataset
uspto-grants-2011_02
Patent number
US07893056B2

Reaction notes

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