1-Amino-2-propanol → HCID 59743156, compound

HRID 1366801Notes

Reaction equation

HRID 1366801 reaction equation
[Cl:1][C:2]1[CH:28]=[C:27]([CH3:29])[C:5]2[N:6]=[C:7]([C:11]3[N:12]([C:20]4[C:25]([Cl:26])=[CH:24][CH:23]=[CH:22][N:21]=4)[N:13]=[C:14]([C:16]([F:19])([F:18])[F:17])[CH:15]=3)[O:8][C:9](=[O:10])[C:4]=2[CH:3]=1.[NH2:30][CH2:31][CH:32]([OH:34])[CH3:33]>C1COCC1>[Cl:1][C:2]1[CH:28]=[C:27]([CH3:29])[C:5]([NH:6][C:7]([C:11]2[N:12]([C:20]3[C:25]([Cl:26])=[CH:24][CH:23]=[CH:22][N:21]=3)[N:13]=[C:14]([C:16]([F:19])([F:18])[F:17])[CH:15]=2)=[O:8])=[C:4]([C:9](=[O:10])[NH:30][CH2:31][CH:32]([OH:34])[CH3:33])[CH:3]=1

Participants

4

Reactant 2

HCID 41-Amino-2-propanolHCID 231503516-chloro-2-[2-(3-chloro-pyridin-2-yl)-5-trifluoromethyl-2H-pyrazol-3-yl]-8-methylbenzo[d][1,3]oxazin-4-one

Product 1

HCID 59743156HCID 59743156, compoundYield 89.5%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of 3.5 g (7.9 mmol) 6-chloro-2-[2-(3-chloro-pyridin-2-yl)-5-trifluoromethyl-2H-pyrazol-3-yl]-8-methylbenzo[d][1,3]oxazin-4-one and 2.5 g 1-amino-2-propanol in 50 ml THF is heated to a temperature of 60° C. for 2 hours. The solvent is then evaporated and the residue is treated with 50 ml hexane. After decantation of the hexane phase, the residue is crystallised in 10 ml isopropanol to give 3.65 g (89%) white crystals (m.p. 193-197° C.).

Workup

  1. customThe solvent is then evaporated
  2. additionthe residue is treated with 50 ml hexane
  3. customAfter decantation of the hexane phase, the residue is crystallised in 10 ml isopropanol

Sources & evidence

ORD record
ord-bc6687645ec247f9bdaa047b9f014a21
Source dataset
uspto-grants-2011_02
Patent number
US07893092B2

Reaction notes

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