Ethylamine → HCID 2982277, compound

HRID 1366825Notes

Reaction equation

HRID 1366825 reaction equation
[CH:1]1[C:6]([S:7](Cl)(=[O:9])=[O:8])=[CH:5][CH:4]=[C:3]([I:11])[CH:2]=1.[CH2:12]([NH2:14])[CH3:13].C(N(CC)CC)C>ClCCl.C1COCC1>[CH2:12]([NH:14][S:7]([C:6]1[CH:5]=[CH:4][C:3]([I:11])=[CH:2][CH:1]=1)(=[O:9])=[O:8])[CH3:13]

Participants

6

Reactant 3

HCID 6341EthylamineHCID 73994-Iodobenzenesulfonyl chlorideHCID 8471Triethylamine

Product 1

HCID 2982277HCID 2982277, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolvent2×HCID 8028TetrahydrofuranSolvent

Procedure

Pipsyl chloride 25 g was dissolved in dichloromethane 250 ml to which was added a solution of ethyl amine 2M, in THF 42 ml and triethylamine 9 g in dichloromethane 100 ml over 30 min. The mixture was stirred a further 1 h at room temperature and then washed with water and 1N hydrochloric acid, dried (MgSO4) and evaporated in vacuo to give N -ethyl-4-iodo-benzenesulfonamide as a white solid, 26.2 g. 1HNMR 7.88 (2H, d), 7.59 (2H, d), 4.65 (1H, m), 3.01 (2H, m), 1.11 (3H, t).

Workup

  1. washwashed with water and 1N hydrochloric acid
  2. dry with materialdried (MgSO4)
  3. customevaporated in vacuo

Sources & evidence

ORD record
ord-0750dcf5365f47d78acf5567125c08eb
Source dataset
uspto-grants-2011_02
Patent number
US07893077B2

Reaction notes

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