反应详情

Phenoxyacetone (5.0240 g, 33.46 mmol) and diethyloxalate (4.52 mL, 33.29 mmol) were mixed together, and then added to a solution of NaOEt (˜3 M, 11.1 mL) stirring in an ice bath under N2. After stirring for 15 minutes, the reaction was warmed to room temperature and stirred overnight. The reaction was quenched at 0° C. with 1N HCl and extracted 2× with CH2Cl2. The combined organics were washed with H2O, dried with Na2SO4, filtered, and concentrated to yield crude 40. The crude material was purified with 1:1 Hexanes:CH2Cl2 to obtain 1.3490 g (15.4%) of 40. 1H (CDCl3, 400 MHz): δ 7.31 (2H, t, J=7.5 Hz), 7.01 (1H, t, J=7.3 Hz), 6.91 (2H, d, J=8.8 Hz), 6.76 (1H, s), 4.67 (2H, s), 4.35 (2H, q, J=7.1 Hz), 1.38 (3H, t, J=7.1 Hz) ppm. 13C (CDCl3, 100 MHz): δ 199.61, 166.38, 161.55, 157.37, 129.63, 121.89, 114.48, 98.97, 70.13, 62.60, 13.90 ppm. DEPT (CDCl3, 100 MHz): CH3 carbons: 13.90; CH2 carbons: 70.13, 62.60; CH carbons: 129.63, 121.89, 114.48, 98.97 ppm. HPLC: 10.180 min. (Starting material: 9.053 min)

1. stirringAfter stirring for 15 minutes
2. stirringstirred overnight
3. customThe reaction was quenched at 0° C. with 1N HCl
4. extractionextracted 2× with CH2Cl2
5. washThe combined organics were washed with H2O
6. dry with materialdried with Na2SO4
7. filtrationfiltered
8. concentrationconcentrated
9. customto yield crude 40
10. customThe crude material was purified with 1:1 Hexanes