反应详情

A mixture of 500 mg of 4-chlorobicyclo[3.2.1]oct-3-en-2-one, 440 mg of ZnCl2, 400 mg of 4-chlorobenzoic acid, 1.05 g of diisopropylethylamine and 5 ml of toluene is stirred at room temperature under a nitrogen atmosphere at reflux temperature for 6 hours. After cooling, the reaction mixture is then diluted with dichloromethane and washed with 5% aqueous sulfuric acid and 5% aqueous sodium hydroxide. After concentration of the organic phase to dryness by evaporation, 0.6 g of 4-(4-chlorophenyl-carbonyloxy)-bicyclo[3.2.1]oct-3-en-2-one is obtained.

1. temperatureat reflux temperature for 6 hours
2. temperatureAfter cooling
3. washwashed with 5% aqueous sulfuric acid and 5% aqueous sodium hydroxide
4. customAfter concentration of the organic phase to dryness by evaporation