Methanesulfonic Acid → HCID 66972614, compound

HRID 1367827Notes

Reaction equation

HRID 1367827 reaction equation
C(OC([NH:8][C@@H:9]([CH2:14][CH2:15][S:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][N:18]=1)[C:10]([O:12][CH3:13])=[O:11])=O)(C)(C)C.CS(O)(=O)=O>C1COCC1>[NH2:8][C@@H:9]([CH2:14][CH2:15][S:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][N:18]=1)[C:10]([O:12][CH3:13])=[O:11]

Participants

4

Reactant 2

HCID 6395Methanesulfonic AcidHCID 66972826HCID 66972826, compound

Product 1

HCID 66972614HCID 66972614, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To methyl 2(S)-tert-butoxycarbonylamino-4-(pyridin-2-ylsulfanyl)butyrate (0.75 g, 2.4 mmol) in THF (5 mL) was added methanesulfonic acid (6.9 g, 7.2 mmol) in one portion. The solution was stirred for 16 h and the crude reaction mixture was concentrated to give methyl 2(S)-amino-4-(pyridin-2-ylsulfanyl)butyrate as the mesylate salt which was used directly in the next step.

Workup

  1. customthe crude reaction mixture
  2. concentrationwas concentrated

Sources & evidence

ORD record
ord-96554ee64b32463b831d902ab4ccf420
Source dataset
uspto-grants-2011_02
Patent number
US07893093B2

Reaction notes

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