Water → tert-Butyl (5,6-dichloropyridin-3-yl)carbamate
Reaction equation
[Cl:1][C:2]1[C:3]([Cl:11])=[N:4][CH:5]=[C:6]([CH:10]=1)C(O)=O.C([N:14]([CH2:17]C)CC)C.O.C(OCC)(=[O:22])C.[C:26]([OH:30])([CH3:29])([CH3:28])[CH3:27]>>[C:26]([O:30][C:17]([NH:14][C:6]1[CH:5]=[N:4][C:3]([Cl:11])=[C:2]([Cl:1])[CH:10]=1)=[O:22])([CH3:29])([CH3:28])[CH3:27]Participants
6
Conditions
- Temperature
- 80 °C
Procedure
To a suspension of 5,6-dichloronicotinic acid (5.1 g) in tert-butyl alcohol (50 ml) were added triethylamine (2.7 g) and phosphorus diphenylazide (7.3 g) in a nitrogen atmosphere and the mixture was heated to 80° C. After 8 hr, the reaction mixture was cooled and water and ethyl acetate were added. The mixture was washed 3 times with water, saturated aqueous sodium hydrogen carbonate solution and saturated brine. The organic layer was dried over anhydrous magnesium sulfate, and the filtrate was concentrated. The residue was applied to flash silica gel chromatography (silica gel, 30 ml) and eluted with hexane:ethyl acetate=5:1-2:1 to give 3-(N-(tert-butoxycarbonyl)amino)-5,6-dichloropyridine as a colorless solid (6.49 g).
Workup
- temperaturethe reaction mixture was cooled
- washThe mixture was washed 3 times with water, saturated aqueous sodium hydrogen carbonate solution and saturated brine
- dry with materialThe organic layer was dried over anhydrous magnesium sulfate
- concentrationthe filtrate was concentrated
- washeluted with hexane
Sources & evidence
- ORD record
- ord-b1ed9aa2d2854974aba022d522024587
- Source dataset
- uspto-grants-2003_06
- Patent number
- US06573274B1
Reaction notes
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