Water → HCID 18520196, compound

HRID 1368271Notes

Reaction equation

HRID 1368271 reaction equation
[Cl:1][C:2]1[N:3]=[C:4]([C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=2)[N:5]([CH2:9][C:10]2[CH:15]=[CH:14][C:13]([S:16]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=3[S:25]([N:28]=CN(C)C)(=[O:27])=[O:26])(=[O:18])=[O:17])=[CH:12][CH:11]=2)[C:6]=1[CH:7]=[O:8].O>CCO.Cl>[Cl:1][C:2]1[N:3]=[C:4]([C:33]2[CH:34]=[CH:35][CH:36]=[CH:37][CH:38]=2)[N:5]([CH2:9][C:10]2[CH:15]=[CH:14][C:13]([S:16]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=3[S:25]([NH2:28])(=[O:26])=[O:27])(=[O:17])=[O:18])=[CH:12][CH:11]=2)[C:6]=1[CH:7]=[O:8]

Participants

5

Reactant 2

HCID 962WaterHCID 57208345HCID 57208345, compound

Product 1

HCID 18520196HCID 18520196, compoundYield 72.7%

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 702EthanolSolvent

Procedure

230 mg of 2-[4-(4-chloro-5-formyl-2-phenylimidazol-1-ylmethyl)benzenesulfonyl]-N-dimethylaminomethylenebenzenesulfonamide are refluxed for 2 h in 3 ml of EtOH and 3 ml of a saturated aqueous HCl solution. The reaction mixture is allowed to cool and poured onto 10 ml of water, and the product is filtered off. Chromatography on silica gel using MTB yields 151 mg of an amorphous solid.

Workup

  1. temperatureto cool
  2. filtrationthe product is filtered off

Sources & evidence

ORD record
ord-3c250b97b83a4d398c0c4c72c6eb4cf9
Source dataset
uspto-grants-2003_06
Patent number
US06573288B1

Reaction notes

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