Hydrazine hydrate (1:1) → HCID 135697913, compound

HRID 1368283Notes

Reaction equation

HRID 1368283 reaction equation
Cl.[CH3:2][O:3][C:4]1[CH:9]=[CH:8][C:7]([CH2:10][C:11]([NH2:13])=[NH:12])=[CH:6][CH:5]=1.O.[NH2:15]N.[C:17]([NH:20][CH:21]([CH3:29])[C:22](=O)[C:23](OCC)=[O:24])(=[O:19])[CH3:18]>>[CH3:2][O:3][C:4]1[CH:5]=[CH:6][C:7]([CH2:10][C:11]2[NH:13][C:23](=[O:24])[C:22]([CH:21]([NH:20][C:17](=[O:19])[CH3:18])[CH3:29])=[N:15][N:12]=2)=[CH:8][CH:9]=1

Participants

4

Reactant 3

HCID 24654Hydrazine hydrate (1:1)HCID 122033942-(4-Methoxyphenyl)ethanimidamide hydrochlorideHCID 22245807Ethyl 3-acetamido-2-oxobutanoate

Product 1

HCID 135697913HCID 135697913, compound

Procedure

Analogously to Example 10A, 5.1 g (25.4 mmol) of 2-(4-methoxyphenyl)ethanamidine hydrochloride are reacted with 1.53 g (30.5 mmol) of hydrazine hydrate and 7.14 g (38.1 mmol) of ethyl 3-(acetylamino)-2-oxobutanoate to give N-{1-[3-(4-methoxybenzyl)-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl]ethyl}acetamide.

Sources & evidence

ORD record
ord-c5164692c10a43078eb064d0de47a043
Source dataset
uspto-grants-2003_06
Patent number
US06573263B2

Reaction notes

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