Hydrazine hydrate (1:1) → HCID 135824715, compound

HRID 1368287Notes

Reaction equation

HRID 1368287 reaction equation
Cl.[N:2]1[C:11]2[C:6](=[CH:7][C:8]([CH2:12][C:13]([NH2:15])=[NH:14])=[CH:9][CH:10]=2)[CH:5]=[CH:4][CH:3]=1.O.[NH2:17]N.[C:19]([NH:22][CH:23]([CH3:31])[C:24](=O)[C:25](OCC)=[O:26])(=[O:21])[CH3:20]>>[O:26]=[C:25]1[C:24]([CH:23]([NH:22][C:19](=[O:21])[CH3:20])[CH3:31])=[N:17][N:15]=[C:13]([CH2:12][C:8]2[CH:7]=[C:6]3[C:11](=[CH:10][CH:9]=2)[N:2]=[CH:3][CH:4]=[CH:5]3)[NH:14]1

Participants

4

Reactant 3

HCID 24654Hydrazine hydrate (1:1)HCID 18519815HCID 18519815, compoundHCID 22245807Ethyl 3-acetamido-2-oxobutanoate

Product 1

HCID 135824715HCID 135824715, compound

Procedure

Analogously to Example 10A, 3.5 g (15.8 mmol) 2-(6-quinolinyl)ethanamidine hydrochloride are reacted with 950 mg (19.0 mmol) of hydrazine hydrate and 4.43 g (23.7 mmol) of ethyl 3-(acetylamino)-2-oxobutanoate to give N-{1-[5-oxo-3-(6-quinolinylmethyl)-4,5-dihydro-1,2,4-triazin-6-yl]ethyl}acetamide.

Sources & evidence

ORD record
ord-3d7ddad725e241d1a3532bf3bd2b6371
Source dataset
uspto-grants-2003_06
Patent number
US06573263B2

Reaction notes

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