反应详情

The amount of 2-acetyl-2-methyl-5-phenylpentanoic acid in 20 ml dichloromethane from Example 38A is reacted analogously to Example 39A with 300 mg (2.20 mmol) of 1-hydroxy-1H-benzotriazole, 670 mg (6.60 mmol) of 4-methylmorpholine, 420 mg (2.20 mmol) of N′-(3-dimethylaminopropyl)-N-ethylcarbodiimide hydrochloride and 620 mg (2.14 mmol) of 6-(1-aminoethyl)-3-(3,4-dimethoxybenzyl)-1,2,4-triazin-5(4H)-one to give 2-acetyl-N-{1-[3-(3,4-dimethoxybenzyl)-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl]ethyl}-2-methyl-5-phenyl-pentanamide.