反应详情

1.44 g (6.50 mmol) 2-(1-hydroxyethyl)-5-phenylpentanoic acid are reacted analogously to Example 39A with 1.00 g (6.50 mmol) of 1-hydroxy-1H-benzotriazole, 1.97 g (19.5 mmol) of 4-methylmorpholine, 1.25 g (6.350 mmol) of N′-(3-dimethylaminopropyl)-N-ethylcarbodiimide hydrochloride and 2.15 g (6.32 mmol) of 6-(1-aminopropyl)-3-(3,4-dimethoxybenzyl)-1,2,4-triazin-5(4H)-one to give N-{1-[3-(3,4-dimethoxybenzyl)-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl]propyl}-2-(1-hydroxyethyl)-5-phenylpentanamide.