4-Methylmorpholine → HCID 135824723, compound

HRID 1368308Notes

Reaction equation

HRID 1368308 reaction equation
[OH:1][CH:2]([CH:4]([CH2:8][CH2:9][CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[C:5]([OH:7])=O)[CH3:3].ON1C2C=CC=CC=2N=N1.CN1CCOCC1.Cl.CN(C)CCCN=C=NCC.[NH2:46][CH:47]([C:50]1[C:51](=[O:67])[NH:52][C:53]([CH2:56][C:57]2[CH:62]=[CH:61][C:60]([O:63][CH3:64])=[C:59]([O:65][CH3:66])[CH:58]=2)=[N:54][N:55]=1)[CH2:48][CH3:49]>>[CH3:66][O:65][C:59]1[CH:58]=[C:57]([CH:62]=[CH:61][C:60]=1[O:63][CH3:64])[CH2:56][C:53]1[NH:52][C:51](=[O:67])[C:50]([CH:47]([NH:46][C:5](=[O:7])[CH:4]([CH:2]([OH:1])[CH3:3])[CH2:8][CH2:9][CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH2:48][CH3:49])=[N:55][N:54]=1

Participants

6

Reactant 5

HCID 79724-MethylmorpholineHCID 757711-HydroxybenzotriazoleHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 183340382-(1-Hydroxyethyl)-5-phenylpentanoic acidHCID 1358247336-(1-aminopropyl)-3-(3,4-dimethoxybenzyl)-1,2,4-triazin-5(4H)-one

Product 1

HCID 135824723HCID 135824723, compound

Procedure

1.44 g (6.50 mmol) 2-(1-hydroxyethyl)-5-phenylpentanoic acid are reacted analogously to Example 39A with 1.00 g (6.50 mmol) of 1-hydroxy-1H-benzotriazole, 1.97 g (19.5 mmol) of 4-methylmorpholine, 1.25 g (6.350 mmol) of N′-(3-dimethylaminopropyl)-N-ethylcarbodiimide hydrochloride and 2.15 g (6.32 mmol) of 6-(1-aminopropyl)-3-(3,4-dimethoxybenzyl)-1,2,4-triazin-5(4H)-one to give N-{1-[3-(3,4-dimethoxybenzyl)-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl]propyl}-2-(1-hydroxyethyl)-5-phenylpentanamide.

Sources & evidence

ORD record
ord-a36910239bf14b378a5990c2924ff719
Source dataset
uspto-grants-2003_06
Patent number
US06573263B2

Reaction notes

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