反应详情

Analogously to Example 40A, 440 mg (305 mmol) of oxalyl chloride, 550 mg (7.00 mmol) of dimethyl sulphoxide, 920 mg (1.82 mmol) of N-{1-[3-(3,4-dimethoxybenzyl)-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl]propyl}-2-(1-hydroxyethyl)-5-phenyl-pentanamide and 1.82 g (18 mmol) of triethylamine are reacted to give 2-acetyl-N-{1-[3-(3,4-dimethoxybenzyl)-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl]propyl}-5-phenylpentanamide.