反应详情

Analogously to Example 40A, 12.9 mg (0.10 mmol) of oxalyl chloride, 9.91 mg (0.13 mmol) of dimethyl sulphoxide, 43.0 mg (0.08 mmol) of N-{1-[3-(3-ethoxy-4-methoxybenzyl)-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl]propyl}2-(1-hydroxyethyl)-5-phenylpentanamide and 32.8 mg (0.25 mmol) of N-ethyldiisopropylamine are reacted to give 2-acetyl-N-{1-[3-(3-ethoxy-4-methoxybenzyl)-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl]propyl}-5-phenylpentanamide.