HCID 18520269, compound → HCID 18520275, compound

HRID 1368374Notes

Reaction equation

HRID 1368374 reaction equation
[ClH:1].C(OCC)(=O)C.[CH3:8][N:9]([CH3:43])[CH2:10][CH2:11][CH2:12][NH:13][C:14](=[O:42])[CH2:15][CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[O:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH3:41]>C(OCC)(=O)C>[ClH:1].[CH3:43][N:9]([CH3:8])[CH2:10][CH2:11][CH2:12][NH:13][C:14](=[O:42])[CH2:15][CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[O:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH3:41]

Participants

4

Reactant 2

HCID 18520269HCID 18520269, compoundHCID 21866389Hydrogen chloride-ethyl acetate

Product 1

HCID 18520275HCID 18520275, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

4N Hydrochloric acid/ethyl acetate solution (0.50 ml) was added to a solution containing N-[3-(dimethylamino)propyl]-3-[2-(octadecyloxy)phenyl]propanamide (0.42 g) in ethyl acetate (4 ml) at room temperature. After being stirred for 10 minutes, the reaction mixture was concentrated. The residue was recrystallized with the mixed solution of ethyl acetate-ethanol, thereby yielding the entitled compound (0.30 g) as white solid.

Workup

  1. concentrationthe reaction mixture was concentrated
  2. customThe residue was recrystallized with the mixed solution of ethyl acetate-ethanol

Sources & evidence

ORD record
ord-352680923de9419c87131e79887d8282
Source dataset
uspto-grants-2003_06
Patent number
US06573297B2

Reaction notes

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