2-[2-(4-Methylpiperazino)-2-oxoethyl]phenyl N-octadecylcarbamate → HCID 18520252, compound

HRID 1368385Notes

Reaction equation

HRID 1368385 reaction equation
[ClH:1].C(OCC)(=O)C.[CH2:8]([NH:26][C:27](=[O:45])[O:28][C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=1[CH2:35][C:36]([N:38]1[CH2:43][CH2:42][N:41]([CH3:44])[CH2:40][CH2:39]1)=[O:37])[CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25]>C(OCC)(=O)C>[ClH:1].[CH2:8]([NH:26][C:27](=[O:45])[O:28][C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=1[CH2:35][C:36]([N:38]1[CH2:39][CH2:40][N:41]([CH3:44])[CH2:42][CH2:43]1)=[O:37])[CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25]

Participants

4

Reactant 2

HCID 185202532-[2-(4-Methylpiperazino)-2-oxoethyl]phenyl N-octadecylcarbamateHCID 21866389Hydrogen chloride-ethyl acetate

Product 1

HCID 18520252HCID 18520252, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

4N Hydrochloric acid/ethyl acetate solution (1.40 ml) was added to a solution containing 2-[2-(4-methylpiperazino)-2-oxoethyl]phenyl N-octadecylcarbamate (2.50 g) in ethyl acetate (25 ml) at room temperature. After being stirred for 30 minutes, the reaction mixture was concentrated. The residue was recrystallized with the mixed solution of ethyl acetate-ethanol, thereby yielding the entitled compound (2.52 g) as white solid.

Workup

  1. concentrationthe reaction mixture was concentrated
  2. customThe residue was recrystallized with the mixed solution of ethyl acetate-ethanol

Sources & evidence

ORD record
ord-361ecb7a0c8b4b3d982365cd87b73bac
Source dataset
uspto-grants-2003_06
Patent number
US06573297B2

Reaction notes

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