Bromobenzene → HCID 178487486, compound

HRID 1368517Notes

Reaction equation

Br[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:8][O:9][C:10]1[CH:11]=[C:12]2[C:17](=[CH:18][CH:19]=1)[CH:16]=[C:15]([C:20]([C:22]1[N:23]=[CH:24][N:25](C(C3C=CC=CC=3)(C3C=CC=CC=3)C3C=CC=CC=3)[CH:26]=1)=[O:21])[CH:14]=[CH:13]2>>[NH:25]1[CH:26]=[C:22]([C:20]([C:15]2[CH:14]=[CH:13][C:12]3[C:17](=[CH:18][CH:19]=[C:10]([O:9][CH3:8])[CH:11]=3)[CH:16]=2)([C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)[OH:21])[N:23]=[CH:24]1

Participants

Reactant 2

HCID 7961Bromobenzene

HCID 11733735(6-Methoxynaphthalen-2-yl)-(1-trityl-1H-imidazol-4-yl)ketone

Product 1

HCID 178487486HCID 178487486, compound

Procedure

In a similar manner to that described in Example 6-(i), the reaction of bromo benzene (0.85 ml) with (6-methoxynaphthalen-2-yl)-(1-trityl-1H-imidazol-4-yl)ketone (1.0 g) was carried out. The reaction mixture was purified by silica gel column chromatography (eluent, hexane:ethyl acetate=3:1→2:1) to give the titled compound (0.98 g) as a pale yellow powder.

Workup

customThe reaction mixture was purified by silica gel column chromatography (eluent, hexane:ethyl acetate=3:1→2:1)

Sources & evidence

ORD record: ord-af224a6b71004f0d835c8be01c8007e6
Source dataset: uspto-grants-2003_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06573289B1

Reaction notes

Loading…