Ethanolamine → HCID 18520435, compound

HRID 1368776Notes

Reaction equation

HRID 1368776 reaction equation
Cl[C:2]1[N:7]=[C:6]([Cl:8])[N:5]=[C:4]([NH:9][CH2:10][C:11]2[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][CH:12]=2)[N:3]=1.[NH2:19][CH2:20][CH2:21][OH:22].C(=O)([O-])[O-].[K+].[K+]>C(O)C>[Cl:8][C:6]1[N:7]=[C:2]([NH:19][CH2:20][CH2:21][OH:22])[N:3]=[C:4]([NH:9][CH2:10][C:11]2[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][CH:12]=2)[N:5]=1

Participants

5

Reactant 3

HCID 700EthanolamineHCID 11430Potassium CarbonateHCID 11300612HCID 11300612, compound

Product 1

HCID 18520435HCID 18520435, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
45 °C

Procedure

A 1.43 g (5.01 mmol) portion of 2,4-dichloro-6-(4-methoxybenzylamino)-1,3,5-triazine was suspended in 100 ml of ethanol, mixed with 303 μl (5.01 mmol) of 2-aminoethanol and 693 mg of potassium carbonate and stirred at 45° C. for 1 day. After evaporation of the solvent under a reduced pressure, water was added to the residue and the resulting precipitate was collected by filtration to obtain 1.56 g (quantitative) of the title compound as a white powder.

Workup

  1. customAfter evaporation of the solvent under a reduced pressure, water
  2. additionwas added to the residue
  3. filtrationthe resulting precipitate was collected by filtration

Sources & evidence

ORD record
ord-90dc0f7fb4634e79820c0c7d0f4da809
Source dataset
uspto-grants-2003_06
Patent number
US06573377B1

Reaction notes

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