Hydrochloric Acid → 2-bromo-4H-thieno[3,2-b]pyrrole-5-carboxylic acid

HRID 1368968Notes

Reaction equation

HRID 1368968 reaction equation
C([O:3][C:4]([C:6]1[NH:10][C:9]2[CH:11]=[C:12]([Br:14])[S:13][C:8]=2[CH:7]=1)=[O:5])C.Cl>>[Br:14][C:12]1[S:13][C:8]2[CH:7]=[C:6]([C:4]([OH:5])=[O:3])[NH:10][C:9]=2[CH:11]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 13164349ethyl 2-bromo-4H-thieno[3,2-b]pyrrole-5-carboxylate

Product 1

HCID 225564902-bromo-4H-thieno[3,2-b]pyrrole-5-carboxylic acid

Procedure

2-Bromo-4H-thieno[3,2-b]pyrrole-5-carboxylic acid ethyl ester (Eras, J.; Galvez, C.; Garcia, F., J. Heterocycl. Chem., 21: 215-217 (1984)) was hydrolyzed according to Procedure D (after cooling to room temperature, acidification with 2 N HCl; resultant precipitate filtered, suspended in toluene, concentrated; no purification).

Workup

  1. filtrationresultant precipitate filtered
  2. concentrationconcentrated
  3. customno purification)

Sources & evidence

ORD record
ord-fbda73132a89485eb889b72ab2d59aa3
Source dataset
uspto-grants-2003_06
Patent number
US06576653B2

Reaction notes

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