4-Pentynoic acid → HCID 18518592, compound

HRID 1369068Notes

Reaction equation

[C:1]([OH:7])(=O)[CH2:2][CH2:3][C:4]#[CH:5].Cl.[CH2:9]([NH:11][CH2:12][CH3:13])[CH3:10]>>[CH2:9]([N:11]([CH2:12][CH3:13])[C:1]([CH2:2][CH2:3][C:4]#[CH:5])=[O:7])[CH3:10]

Participants

Reactant 2

HCID 224644-Pentynoic acid

HCID 10197650Diethylammonium chloride

Product 1

HCID 18518592HCID 18518592, compoundYield 95%

Procedure

The title compound (370 mg, 95%) was prepared from 4-pentynoic acid (250 mg, 2.55 mmol) and diethylamine hydrochloride (310 mg, 2.83 mmol) by the procedure similar to that described in Example 51(1).

Sources & evidence

ORD record: ord-cfc4c20c27ef4b7c8934c32aef8d9fbe
Source dataset: uspto-grants-2003_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06576656B1

Reaction notes

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