Hydrochloric Acid → HCID 178460452, compound

HRID 1369193Notes

Reaction equation

HRID 1369193 reaction equation
[C:1]([O:5][C:6]([C@@:9]12[CH2:18][CH2:17][CH2:16][CH2:15][C@:14]1([O:19]COCCOC)[CH2:13][CH2:12][CH2:11][CH2:10]2)([CH3:8])[CH3:7])(=[O:4])[CH:2]=[CH2:3].Cl>CC(C)=O>[C:1]([O:5][C:6]([C@@:9]12[CH2:18][CH2:17][CH2:16][CH2:15][C@:14]1([OH:19])[CH2:13][CH2:12][CH2:11][CH2:10]2)([CH3:8])[CH3:7])(=[O:4])[CH:2]=[CH2:3]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178460454HCID 178460454, compound

Product 1

HCID 178460452HCID 178460452, compoundYield 98%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

A mixture of 100 mmol of 4a-(1-acryloyloxy-1-methylethyl)-8a-(2-methoxyethoxymethoxy)-cis-decalin, 6 N-hydrochloric acid (150 mmol in terms of HCl), and 30 ml of acetone was stirred at room temperature for 1 hour. The resulting reaction mixture was concentrated to yield 4a-(1-acryloyloxy-1-methylethyl)-8a-hydroxy-cis-decalin represented by the following formula (yield: 98%). The conversion rate from 4a-(1-acryloyloxy-1-methylethyl)-8a-(2-methoxyethoxymethoxy)-cis-decalin was 99%.

Workup

  1. customThe resulting reaction mixture
  2. concentrationwas concentrated

Sources & evidence

ORD record
ord-baae4739a5fb4c65b87bdf0dfa3a6dd8
Source dataset
uspto-grants-2003_06
Patent number
US06576787B1

Reaction notes

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