Trifluoroacetic acid → HCID 18518384, compound

HRID 1369248Notes

Reaction equation

HRID 1369248 reaction equation
[C:1]1([NH:11][CH2:12][CH2:13][CH2:14][O:15][C:16]2[CH:17]=[CH:18][C:19]3[CH2:25][CH:24]([CH2:26][C:27]([O:29]CC)=[O:28])[C:23]4[CH:32]=[CH:33][CH:34]=[CH:35][C:22]=4[CH2:21][C:20]=3[CH:36]=2)[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][N:2]=1.N1C=CC=CC=1NCCCOC1C=CC2C[C@H](CC(OCC)=O)C3C=CC=CC=3CC=2C=1.C(O)(C(F)(F)F)=O>O>[C:1]1([NH:11][CH2:12][CH2:13][CH2:14][O:15][C:16]2[CH:36]=[C:20]3[CH2:21][C:22]4[CH:35]=[CH:34][CH:33]=[CH:32][C:23]=4[CH:24]([CH2:26][C:27]([OH:29])=[O:28])[CH:25]=[C:19]3[CH2:18][CH:17]=2)[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][N:2]=1

Participants

5

Reactant 3

HCID 6422Trifluoroacetic acidHCID 12071478HCID 12071478, compoundHCID 86585475HCID 86585475, compound

Product 1

HCID 18518384HCID 18518384, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

According to the procedure of Example 6 (c), except substituting ethyl (±)-10,11-dihydro-3-[3-(isoquinoline-1-ylamino)-1-propyloxy]-5H-dibenzo[a,d]cycloheptene-10-acetate for the ethyl (R)-10,11-dihydro-3-[3-(pyridin-2-ylamino)-1-propyloxy]-5H-dibenzo[a,d]cycloheptene-10-acetate, the title compound was prepared as an amber solid: MS (ES) m/e 453.2(M+H)+. Anal. Calcd for C29H28N2O3.1.3 TFA.0.25 H2O: C, 62.71; H, 4.96; N, 4.63. Found: C, 62.45; H, 4.92; N, 4.41.

Sources & evidence

ORD record
ord-f9c2013775ee4e33b4921e4088658be5
Source dataset
uspto-grants-2003_06
Patent number
US06576643B2

Reaction notes

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