反应详情

N-Methyl piperazine (0.2 mol) and 1-bromo-3-chloropropane (0.1 mol) in toluene (100 mL) were heated at 80° C. for 3 hr. The precipitate was collected and the remaining filtrate extracted with HCl (1N, 2×50 mL). The aqueous layer was made basic with NaOH (1N) and extracted with ether (3×100 mL). The combined ether layers were washed with water, dried (MgSO4), filtered and evaporated to afford product as a pale yellow oil.

1. customThe precipitate was collected
2. extractionthe remaining filtrate extracted with HCl (1N, 2×50 mL)
3. extractionextracted with ether (3×100 mL)
4. washThe combined ether layers were washed with water
5. dry with materialdried (MgSO4)
6. filtrationfiltered
7. customevaporated
8. customto afford product as a pale yellow oil