huagongshe.com
HRID1369602

反应详情

EQUATION

反应方程式

HRID 1369602 的结构方程式

REACTANTS

反应物

2
结构：Cl
HCID313

Hydrochloric Acid

ClH

结构：CCOC(=O)c1cn(C[C@H]2CC[C@H]3CN[C@H](C(=O)OCC)C[C@H]3C2)cn1
HCID9799112

未命名化合物

PRODUCTS

生成物

1
结构：CCOC(=O)c1cn(C[C@H]2CC[C@H]3CN[C@H](C(=O)OCC)C[C@H]3C2)cn1.Cl.Cl
HCID20594298

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

2
结构：CCOCC
溶剂HCID3283

Diethyl Ether

C4H10O

结构：CCOC(C)=O
溶剂HCID8857

Ethyl acetate

C4H8O2

PROCEDURE

实验过程

[3S,4aR,6S,8aR]-Ethyl-6-((4-ethoxycarbonyl-1H-imidazol-1-yl)methyl)-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylate was dissolved in ethyl acetate and excess 1M HCl in diethyl ether was added. The resulting white precipitate was filtered and vacuum dried at 50° C. for 18 hr to give 0.62 g of [3S,4aR,6S,8aR]-ethyl-6-((4-ethoxycarbonyl-1H-imidazol-1-yl)methyl)-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylate dihydrochloride: MS m/z: 364 (m++1); Analysis calculated for C19H29N3O4.2HCl H2O: C, 50.20; H, 6.89; N, 9.25. Found: C, 50.51; H, 6.86; N, 9.25.

WORKUP

后处理

  1. filtrationThe resulting white precipitate was filtered
  2. customvacuum dried at 50° C. for 18 hr