Methanesulfonic Acid → [3S,4aR,6S,8aR]-Ethyl-6-((4-Ethoxycarbonyl-1H-Imidazol-1-yl)Methyl)-1,2,3,4,4a,5,6,7,8,8a-Decahydroisoquinoline-3-Carboxylate

HRID 1369604Notes

Reaction equation

HRID 1369604 reaction equation
[CH3:1][S:2]([OH:5])(=[O:4])=[O:3].[CH2:6]([O:8][C:9]([C@@H:11]1[CH2:20][C@@H:19]2[C@@H:14]([CH2:15][CH2:16][C@H:17]([CH2:21][N:22]3[CH:26]=[C:25]([C:27]([O:29][CH2:30][CH3:31])=[O:28])[N:24]=[CH:23]3)[CH2:18]2)[CH2:13][NH:12]1)=[O:10])[CH3:7]>C(OCC)(=O)C>[CH3:1][S:2]([OH:5])(=[O:4])=[O:3].[CH2:6]([O:8][C:9]([C@@H:11]1[CH2:20][C@@H:19]2[C@@H:14]([CH2:15][CH2:16][C@H:17]([CH2:21][N:22]3[CH:26]=[C:25]([C:27]([O:29][CH2:30][CH3:31])=[O:28])[N:24]=[CH:23]3)[CH2:18]2)[CH2:13][NH:12]1)=[O:10])[CH3:7].[CH2:6]([O:8][C:9]([C@@H:11]1[CH2:20][C@@H:19]2[C@@H:14]([CH2:15][CH2:16][C@H:17]([CH2:21][N:22]3[CH:26]=[C:25]([C:27]([O:29][CH2:30][CH3:31])=[O:28])[N:24]=[CH:23]3)[CH2:18]2)[CH2:13][NH:12]1)=[O:10])[CH3:7]

Participants

5

Reactant 2

HCID 6395Methanesulfonic AcidHCID 9799112[3S,4aR,6S,8aR]-Ethyl-6-((4-Ethoxycarbonyl-1H-Imidazol-1-yl)Methyl)-1,2,3,4,4a,5,6,7,8,8a-Decahydroisoquinoline-3-Carboxylate

Product 2

HCID 9799112[3S,4aR,6S,8aR]-Ethyl-6-((4-Ethoxycarbonyl-1H-Imidazol-1-yl)Methyl)-1,2,3,4,4a,5,6,7,8,8a-Decahydroisoquinoline-3-CarboxylateHCID 20594302[3S,4aR,6S,8aR]-Ethyl-6-((4-Ethoxycarbonyl-1H-Imidazol-1-yl)Methyl)-1,2,3,4,4a,5,6,7,8,8a-Decahydroisoquinoline-3-Carboxylate Methanesulfonate

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

The methanesulfonic acid salt of [3S,4aR,6S,8aR]-Ethyl-6-((4-ethoxycarbonyl-1H-imidazol-1-yl)methyl)-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylate is prepared in a manner analogous to the procedures described above from one equivalent of methanesulfonic acid and one equivalent of [3S,4aR,6S,8aR]-Ethyl-6-((4-ethoxycarbonyl-1H-imidazol-1-yl)methyl)-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylate in ethyl acetate.

Sources & evidence

ORD record
ord-a62916c597154eb5ab8152468376c7c9
Source dataset
uspto-grants-2003_06
Patent number
US06579886B2

Reaction notes

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