HRID1369604

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6395

Methanesulfonic acid

CH4O3S

结构：CCOC(=O)c1cn(C[C@H]2CC[C@H]3CN[C@H](C(=O)OCC)C[C@H]3C2)cn1

HCID9799112

未命名化合物

PRODUCTS

生成物

HCID9799112

未命名化合物

结构：CCOC(=O)c1cn(C[C@H]2CC[C@H]3CN[C@H](C(=O)OCC)C[C@H]3C2)cn1.CS(=O)(=O)O

HCID20594302

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID8857

Ethyl acetate

C4H8O2

PROCEDURE

实验过程

The methanesulfonic acid salt of [3S,4aR,6S,8aR]-Ethyl-6-((4-ethoxycarbonyl-1H-imidazol-1-yl)methyl)-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylate is prepared in a manner analogous to the procedures described above from one equivalent of methanesulfonic acid and one equivalent of [3S,4aR,6S,8aR]-Ethyl-6-((4-ethoxycarbonyl-1H-imidazol-1-yl)methyl)-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylate in ethyl acetate.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-a62916c597154eb5ab8152468376c7c9
来源数据集: uspto-grants-2003_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06579886B2
来源说明: uspto-grants-2003_06

反应 SMILES

[CH3:1][S:2]([OH:5])(=[O:4])=[O:3].[CH2:6]([O:8][C:9]([C@@H:11]1[CH2:20][C@@H:19]2[C@@H:14]([CH2:15][CH2:16][C@H:17]([CH2:21][N:22]3[CH:26]=[C:25]([C:27]([O:29][CH2:30][CH3:31])=[O:28])[N:24]=[CH:23]3)[CH2:18]2)[CH2:13][NH:12]1)=[O:10])[CH3:7]>C(OCC)(=O)C>[CH3:1][S:2]([OH:5])(=[O:4])=[O:3].[CH2:6]([O:8][C:9]([C@@H:11]1[CH2:20][C@@H:19]2[C@@H:14]([CH2:15][CH2:16][C@H:17]([CH2:21][N:22]3[CH:26]=[C:25]([C:27]([O:29][CH2:30][CH3:31])=[O:28])[N:24]=[CH:23]3)[CH2:18]2)[CH2:13][NH:12]1)=[O:10])[CH3:7].[CH2:6]([O:8][C:9]([C@@H:11]1[CH2:20][C@@H:19]2[C@@H:14]([CH2:15][CH2:16][C@H:17]([CH2:21][N:22]3[CH:26]=[C:25]([C:27]([O:29][CH2:30][CH3:31])=[O:28])[N:24]=[CH:23]3)[CH2:18]2)[CH2:13][NH:12]1)=[O:10])[CH3:7]