反应详情

A solution of 200 mg (0.6 mmol) of 5-tert-butoxycarbonyl-3a,6-difluoro-1,2,3,3a,5,9b-hexahydrocyclopenta[c]quinolin-4-one in 2 ml of dichloromethane is mixed with 2 ml of trifluoroacetic acid at room temperature. After 30 minutes, the batch is diluted with water and ethyl acetate. The organic phase is separated, washed with water, saturated NaHCO3 and saturated NaCl, dried (Na2SO4) and concentrated by evaporation in a vacuum. Column chromatography of the residue on silica gel with hexane-ethyl acetate yields 60 mg of product.

1. customThe organic phase is separated
2. washwashed with water, saturated NaHCO3 and saturated NaCl
3. dry with materialdried (Na2SO4)
4. concentrationconcentrated by evaporation in a vacuum