Sodium Iodide → 2,3-Dihydro-1H-3a,6-diaza-cyclopenta[a]indene

To a solution of 4-Amino-3-iodopyridine (2.2 g, 10.00 mMol) in acetonitrile (25 ml), was added dropwise trifluoroacetic anhydride (2.53 g, 1.674 ml) at 0° C. followed by addition of potassium carbonate (4.14 g, 30 mMol). The mixture was stirred at room temperature for 10 min. To the resulting suspension was added bis(triphenylphosphine)-palladium(II)chloride (0.175 g, 0.25 mMol), copper(I)iodide (0.095 g, 0.50 mMol) and 5-chloro-1-pentyne (1.23 g, 12.00 mMol) and the mixture was heated to reflux under argon for 3 h. The mixture was cooled to room temperature and partitioned between water and ethyl acetate. The phases were separated. The organic phase was extracted with water at pH 1.00. The acidic aqueous phase was mixed with dichloromethane and the pH was raised to 10 by addition of 2N NaOH. The phases were separated and the organic phase was dried over sodium sulfate. The solvent was evaporated and the residue was taken up in acetonitrile (20 ml). To the brownish solution was added sodium iodide (3.00 g, 20 mMol) and sodium hydride (ca 55% 0.873 g, 20 mMol) and the mixture was stirred at room temperature for 2 h. The mixture was poured onto ice and partitioned between water and ethyl acetate (100 ml water 100 ml ethyl acetate). The phases were separated. The organic phase was extracted with water at pH 1.00 (5×50 ml). The combined acidic aqueous phases were mixed with dichloromethane (100 ml) and the pH was raised to 10 by addition of 2N NaOH. The phases were separated and the organic phase was dried over sodium sulfate. The solvent was evaporated and the title compound (0.81 g, 51% of theory) was obtained as a brownish solid. For analytical purposes a sample was recrystallised from t-butylmethylether to afford light brown crystals melting at 95-96° C.; Found C, 75.93; H. 6.32; N,17.80%. C10H10N2 requires: C, 75.92; H, 6.37; N, 17.71%

1. temperaturethe mixture was heated
2. temperatureto reflux under argon for 3 h
3. temperatureThe mixture was cooled to room temperature
4. custompartitioned between water and ethyl acetate
5. customThe phases were separated
6. extractionThe organic phase was extracted with water at pH 1.00
7. additionThe acidic aqueous phase was mixed with dichloromethane
8. temperaturethe pH was raised to 10 by addition of 2N NaOH
9. customThe phases were separated
10. dry with materialthe organic phase was dried over sodium sulfate
11. customThe solvent was evaporated
12. stirringthe mixture was stirred at room temperature for 2 h
13. additionThe mixture was poured onto ice
14. custompartitioned between water and ethyl acetate (100 ml water 100 ml ethyl acetate)
15. customThe phases were separated
16. extractionThe organic phase was extracted with water at pH 1.00 (5×50 ml)
17. additionThe combined acidic aqueous phases were mixed with dichloromethane (100 ml)
18. temperaturethe pH was raised to 10 by addition of 2N NaOH
19. customThe phases were separated
20. dry with materialthe organic phase was dried over sodium sulfate
21. customThe solvent was evaporated

ORD record

ord-43294dd77ec94c37ac15ffd6e3866642

Source dataset

uspto-grants-2003_06

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06583134B2