Phenyl Isothiocyanate → HCID 18511664, compound

HRID 1370532Notes

Reaction equation

HRID 1370532 reaction equation
[C:1]1([N:7]=[C:8]=[S:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl.Cl.[F:12][C:13]1[CH:31]=[CH:30][C:16]([O:17][CH2:18][CH2:19][CH2:20][CH2:21][N:22]2[CH2:27][CH2:26][CH:25]([NH:28][CH3:29])[CH2:24][CH2:23]2)=[CH:15][CH:14]=1>>[CH3:29][N:28]([CH:25]1[CH2:24][CH2:23][N:22]([CH2:21][CH2:20][CH2:19][CH2:18][O:17][C:16]2[CH:15]=[CH:14][C:13]([F:12])=[CH:31][CH:30]=2)[CH2:27][CH2:26]1)[C:8]([NH:7][C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1)=[S:9]

Participants

3

Reactant 2

HCID 7673Phenyl IsothiocyanateHCID 185116461-[4-(4-Fluorophenoxy)butyl]-4-methylaminopiperidine dihydrochloride

Product 1

HCID 18511664HCID 18511664, compound

Procedure

The condensation of 2 g (14.8 mmol) of phenyl isothiocyanate with 5.25 g (14.8 mmol) of 1-[4-(4-fluorophenoxy)butyl]-4-methylaminopiperidine dihydrochloride (cf. WO 97/05134) according to the protocol of Example 1.1 provides 5.5 g (Yd: 90%) of white crystals of formula 7.1:

Sources & evidence

ORD record
ord-480dcf4e93fd4c948256b2ee20c5be4d
Source dataset
uspto-grants-2003_06
Patent number
US06583159B1

Reaction notes

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