4-Fluorophenyl isothiocyanate → HCID 18511660, compound

HRID 1370537Notes

Reaction equation

HRID 1370537 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:18]=[CH:19][C:20]=1[F:21])[O:5][CH2:6][CH2:7][CH2:8][CH2:9][N:10]1[CH2:15][CH2:14][CH:13]([NH:16][CH3:17])[CH2:12][CH2:11]1.[F:22][C:23]1[CH:28]=[CH:27][C:26]([N:29]=[C:30]=[S:31])=[CH:25][CH:24]=1>C1COCC1>[CH3:17][N:16]([CH:13]1[CH2:12][CH2:11][N:10]([CH2:9][CH2:8][CH2:7][CH2:6][O:5][C:4]2[CH:18]=[CH:19][C:20]([F:21])=[C:2]([F:1])[CH:3]=2)[CH2:15][CH2:14]1)[C:30]([NH:29][C:26]1[CH:27]=[CH:28][C:23]([F:22])=[CH:24][CH:25]=1)=[S:31]

Participants

4

Reactant 2

HCID 152414-Fluorophenyl isothiocyanateHCID 11738079HCID 11738079, compound

Product 1

HCID 18511660HCID 18511660, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The condensation of 1.2 g (4 mmol) of 1-[4-(3,4-difluorophenoxy)butyl]-4-(methylamino)piperidine with 0.61 g (4 mmol) of 4-fluorophenyl isothiocyanate in THF according to the protocol of Example 1.1 gives 1.75 g (Yd: 95%) of a powder of formula 13.1

Sources & evidence

ORD record
ord-f8f04fa01aec4c30b0ccf2b80ad95483
Source dataset
uspto-grants-2003_06
Patent number
US06583159B1

Reaction notes

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